Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference

RNA interference (RNAi) technology provides a powerful molecular tool to reduce an expression of selected genes in eukaryotic cells. Short interfering RNAs (siRNAs) are the effector molecules that trigger RNAi. Here, we describe siRNAs that discriminate between the wild type and mutant (1174 C→G) al...

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Bibliographische Detailangaben
Hauptverfasser: Sierant, Malgorzata, Paduszynska, Alina, Kazmierczak-Baranska, Julia, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Sochacka, Elzbieta, Nawrot, Barbara
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE-Hindawi Access to Research 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090069/
https://ncbi.nlm.nih.gov/pubmed/21559198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/809218
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