Evaluation of BACE1 Silencing in Cellular Models

Beta-secretase (BACE1) is the major enzyme participating in generation of toxic amyloid-beta (Aβ) peptides, identified in amyloid plaques of Alzheimer's disease (AD) brains. Its downregulation results in decreasing secretion of Aβ. Thus, BACE1 silencing by RNAi represents possible strategy for...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sierant, Malgorzata, Kubiak, Katarzyna, Kazmierczak-Baranska, Julia, Warashina, Masaki, Kuwabara, Tomoko, Nawrot, Barbara
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SAGE-Hindawi Access to Research 2009
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915613/
https://ncbi.nlm.nih.gov/pubmed/20721293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2009/257403
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