Evaluation of BACE1 Silencing in Cellular Models

Beta-secretase (BACE1) is the major enzyme participating in generation of toxic amyloid-beta (Aβ) peptides, identified in amyloid plaques of Alzheimer's disease (AD) brains. Its downregulation results in decreasing secretion of Aβ. Thus, BACE1 silencing by RNAi represents possible strategy for...

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Detalhes bibliográficos
Main Authors: Sierant, Malgorzata, Kubiak, Katarzyna, Kazmierczak-Baranska, Julia, Warashina, Masaki, Kuwabara, Tomoko, Nawrot, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915613/
https://ncbi.nlm.nih.gov/pubmed/20721293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2009/257403
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