Allele-specific RNAi Mitigates Phenotypic Progression in a Transgenic Model of Alzheimer's Disease

Despite recent advances suggesting new therapeutic targets, Alzheimer's disease (AD) remains incurable. Aberrant production and accumulation of the Aβ peptide resulting from altered processing of the amyloid precursor protein (APP) is central to the pathogenesis of disease, particularly in domi...

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Detaylı Bibliyografya
Asıl Yazarlar: Rodríguez-Lebrón, Edgardo, Gouvion, Cynthia M, Moore, Steven A, Davidson, Beverly L, Paulson, Henry L
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2009
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835271/
https://ncbi.nlm.nih.gov/pubmed/19532137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.123
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