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DNA/Amphiphilic Block Copolymer Nanospheres Promote Low-dose DNA Vaccination
Intramuscular (i.m.) DNA vaccination induces strong cellular immune responses in the mouse, but only at DNA doses that cannot be achieved in humans. Because antigen expression is weak after naked DNA injection, we screened five nonionic block copolymers of poly(ethyleneoxide)-poly(propyleneoxide) (P...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835232/ https://ncbi.nlm.nih.gov/pubmed/19417740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.84 |
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