DNA/Amphiphilic Block Copolymer Nanospheres Promote Low-dose DNA Vaccination

Intramuscular (i.m.) DNA vaccination induces strong cellular immune responses in the mouse, but only at DNA doses that cannot be achieved in humans. Because antigen expression is weak after naked DNA injection, we screened five nonionic block copolymers of poly(ethyleneoxide)-poly(propyleneoxide) (P...

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Main Authors: McIlroy, Dorian, Barteau, Benoît, Cany, Jeannette, Richard, Peggy, Gourden, Clothilde, Conchon, Sophie, Pitard, Bruno
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2009
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Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835232/
https://ncbi.nlm.nih.gov/pubmed/19417740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.84
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