DNA/Amphiphilic Block Copolymer Nanospheres Promote Low-dose DNA Vaccination

Intramuscular (i.m.) DNA vaccination induces strong cellular immune responses in the mouse, but only at DNA doses that cannot be achieved in humans. Because antigen expression is weak after naked DNA injection, we screened five nonionic block copolymers of poly(ethyleneoxide)-poly(propyleneoxide) (P...

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Autors principals: McIlroy, Dorian, Barteau, Benoît, Cany, Jeannette, Richard, Peggy, Gourden, Clothilde, Conchon, Sophie, Pitard, Bruno
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835232/
https://ncbi.nlm.nih.gov/pubmed/19417740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.84
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