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DNA/Amphiphilic Block Copolymer Nanospheres Promote Low-dose DNA Vaccination

Intramuscular (i.m.) DNA vaccination induces strong cellular immune responses in the mouse, but only at DNA doses that cannot be achieved in humans. Because antigen expression is weak after naked DNA injection, we screened five nonionic block copolymers of poly(ethyleneoxide)-poly(propyleneoxide) (P...

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Detalhes bibliográficos
Main Authors: McIlroy, Dorian, Barteau, Benoît, Cany, Jeannette, Richard, Peggy, Gourden, Clothilde, Conchon, Sophie, Pitard, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835232/
https://ncbi.nlm.nih.gov/pubmed/19417740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.84
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