Amphiphilic Block Copolymers Enhance Cellular Uptake and Nuclear Entry of Polyplex-Delivered DNA

This work for the first time demonstrates that synthetic polymers enhance uptake and nuclear import of plasmid DNA (pDNA) through the activation of cellular trafficking machinery. Nonionic block copolymers of poly(ethylene oxide) and poly(propylene oxide), Pluronics, are widely used as excipients in...

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Bibliografiske detaljer
Main Authors: Yang, Zhihui, Sahay, Gaurav, Sriadibhatla, Srikanth, Kabanov, Alexander V.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574534/
https://ncbi.nlm.nih.gov/pubmed/18729495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800144a
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