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Amphiphilic Block Copolymers Enhance Cellular Uptake and Nuclear Entry of Polyplex-Delivered DNA

This work for the first time demonstrates that synthetic polymers enhance uptake and nuclear import of plasmid DNA (pDNA) through the activation of cellular trafficking machinery. Nonionic block copolymers of poly(ethylene oxide) and poly(propylene oxide), Pluronics, are widely used as excipients in...

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Detalles Bibliográficos
Main Authors: Yang, Zhihui, Sahay, Gaurav, Sriadibhatla, Srikanth, Kabanov, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574534/
https://ncbi.nlm.nih.gov/pubmed/18729495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800144a
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