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Pluronic-based cationic block copolymer for forming pDNA polyplexes with enhanced cellular uptake and improved transfection efficiency

PEGylated cationic polymers have been extensively studied for substituting virus as gene delivery vehicles. These polymers can produce water-soluble polyionic complexes (polyplexes) with plasmid DNA (pDNA) and show enhanced stability compared to non-PEGylated polyplexes. However, PEGylation always d...

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Bibliografiske detaljer
Main Authors: Lai, Tsz Chung, Kataoka, Kazunori, Kwon, Glen S.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094566/
https://ncbi.nlm.nih.gov/pubmed/21453964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2011.02.065
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