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Genetic Manipulation of Tumor-specific Cytotoxic T Lymphocytes to Restore Responsiveness to IL-7

Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) can induce objective clinical responses in patients with malignant diseases. The option of providing a proliferative and survival advantage to adoptively transferred CTLs remains a challenge to improve their efficacy. Host lymphode...

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Detalhes bibliográficos
Main Authors: Vera, Juan F, Hoyos, Valentina, Savoldo, Barbara, Quintarelli, Concetta, Giordano Attianese, Greta MP, Leen, Ann M, Liu, Hao, Foster, Aaron E, Heslop, Helen E, Rooney, Cliona M, Brenner, Malcolm K, Dotti, Gianpietro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835146/
https://ncbi.nlm.nih.gov/pubmed/19259067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.34
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