High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells

The cancer testis antigen (CTA) preferentially expressed antigen of melanoma (PRAME) is overexpressed by many hematologic malignancies, but is absent on normal tissues, including hematopoietic progenitor cells, and may therefore be an appropriate candidate for T cell–mediated immunotherapy. Because...

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Bibliographic Details
Main Authors: Quintarelli, Concetta, Dotti, Gianpietro, Hasan, Sayyeda T., De Angelis, Biagio, Hoyos, Valentina, Errichiello, Santa, Mims, Martha, Luciano, Luigia, Shafer, Jessica, Leen, Ann M., Heslop, Helen E., Rooney, Cliona M., Pane, Fabrizio, Brenner, Malcolm K., Savoldo, Barbara
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069675/
https://ncbi.nlm.nih.gov/pubmed/21278353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-300376
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