High-avidity cytotoxic T lymphocytes specific for a new PRAME-derived peptide can target leukemic and leukemic-precursor cells

The cancer testis antigen (CTA) preferentially expressed antigen of melanoma (PRAME) is overexpressed by many hematologic malignancies, but is absent on normal tissues, including hematopoietic progenitor cells, and may therefore be an appropriate candidate for T cell–mediated immunotherapy. Because...

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Detalles Bibliográficos
Main Authors: Quintarelli, Concetta, Dotti, Gianpietro, Hasan, Sayyeda T., De Angelis, Biagio, Hoyos, Valentina, Errichiello, Santa, Mims, Martha, Luciano, Luigia, Shafer, Jessica, Leen, Ann M., Heslop, Helen E., Rooney, Cliona M., Pane, Fabrizio, Brenner, Malcolm K., Savoldo, Barbara
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2011
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069675/
https://ncbi.nlm.nih.gov/pubmed/21278353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-300376
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