Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter

Tricyclic antidepressants (TCAs) have been used for decades, but their orientation within and molecular interactions with their primary target is yet unsettled. The recent finding of a TCA binding site in the extracellular vestibule of the bacterial leucine transporter 11 Å above the central site ha...

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Bibliografiske detaljer
Main Authors: Sinning, Steffen, Musgaard, Maria, Jensen, Marie, Severinsen, Kasper, Celik, Leyla, Koldsø, Heidi, Meyer, Tine, Bols, Mikael, Jensen, Henrik Helligsø, Schiøtt, Birgit, Wiborg, Ove
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832986/
https://ncbi.nlm.nih.gov/pubmed/19948720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045401
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