Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter

Tricyclic antidepressants (TCAs) have been used for decades, but their orientation within and molecular interactions with their primary target is yet unsettled. The recent finding of a TCA binding site in the extracellular vestibule of the bacterial leucine transporter 11 Å above the central site ha...

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Hlavní autoři: Sinning, Steffen, Musgaard, Maria, Jensen, Marie, Severinsen, Kasper, Celik, Leyla, Koldsø, Heidi, Meyer, Tine, Bols, Mikael, Jensen, Henrik Helligsø, Schiøtt, Birgit, Wiborg, Ove
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832986/
https://ncbi.nlm.nih.gov/pubmed/19948720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045401
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