Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter

Tricyclic antidepressants (TCAs) have been used for decades, but their orientation within and molecular interactions with their primary target is yet unsettled. The recent finding of a TCA binding site in the extracellular vestibule of the bacterial leucine transporter 11 Å above the central site ha...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sinning, Steffen, Musgaard, Maria, Jensen, Marie, Severinsen, Kasper, Celik, Leyla, Koldsø, Heidi, Meyer, Tine, Bols, Mikael, Jensen, Henrik Helligsø, Schiøtt, Birgit, Wiborg, Ove
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Membrane Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832986/
https://ncbi.nlm.nih.gov/pubmed/19948720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045401
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