Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter

Tricyclic antidepressants (TCAs) have been used for decades, but their orientation within and molecular interactions with their primary target is yet unsettled. The recent finding of a TCA binding site in the extracellular vestibule of the bacterial leucine transporter 11 Å above the central site ha...

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Dettagli Bibliografici
Autori principali: Sinning, Steffen, Musgaard, Maria, Jensen, Marie, Severinsen, Kasper, Celik, Leyla, Koldsø, Heidi, Meyer, Tine, Bols, Mikael, Jensen, Henrik Helligsø, Schiøtt, Birgit, Wiborg, Ove
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Membrane Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832986/
https://ncbi.nlm.nih.gov/pubmed/19948720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045401
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