Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter

The serotonin transporter (SERT) is important for reuptake of the neurotransmitter serotonin from the synaptic cleft and is also the target of most antidepressants. It has previously been shown that cholesterol in the membrane bilayer affects the conformation of SERT. Although recent crystal structu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Laursen, Louise, Severinsen, Kasper, Kristensen, Kristina Birch, Periole, Xavier, Overby, Malene, Müller, Heidi Kaastrup, Schiøtt, Birgit, Sinning, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846164/
https://ncbi.nlm.nih.gov/pubmed/29352106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809046
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