A Dualistic Conformational Response to Substrate Binding in the Human Serotonin Transporter Reveals a High Affinity State for Serotonin

Serotonergic neurotransmission is modulated by the membrane-embedded serotonin transporter (SERT). SERT mediates the reuptake of serotonin into the presynaptic neurons. Conformational changes in SERT occur upon binding of ions and substrate and are crucial for translocation of serotonin across the m...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Bjerregaard, Henriette, Severinsen, Kasper, Said, Saida, Wiborg, Ove, Sinning, Steffen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367276/
https://ncbi.nlm.nih.gov/pubmed/25614630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.573477
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