Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter

Tricyclic antidepressants (TCAs) have been used for decades, but their orientation within and molecular interactions with their primary target is yet unsettled. The recent finding of a TCA binding site in the extracellular vestibule of the bacterial leucine transporter 11 Å above the central site ha...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sinning, Steffen, Musgaard, Maria, Jensen, Marie, Severinsen, Kasper, Celik, Leyla, Koldsø, Heidi, Meyer, Tine, Bols, Mikael, Jensen, Henrik Helligsø, Schiøtt, Birgit, Wiborg, Ove
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832986/
https://ncbi.nlm.nih.gov/pubmed/19948720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045401
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares