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Amifostine Metabolite WR-1065 Disrupts Homologous Recombination in Mammalian Cells

Repair of DNA damage through homologous recombination (HR) pathways plays a crucial role in maintaining genome stability. However, overstimulation of HR pathways in response to genotoxic stress may abnormally elevate recombination frequencies, leading to increased mutation rates and delayed genomic...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dziegielewski, Jaroslaw, Goetz, Wilfried, Murley, Jeffrey S., Grdina, David J., Morgan, William F., Baulch, Janet E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831807/
https://ncbi.nlm.nih.gov/pubmed/20095849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1982.1
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