Mammalian cell polyamine homeostasis is altered by the radioprotector WR1065.

Mammalian cells become more susceptible to radiation-induced death and mutagenesis when restricted in their production of the natural polyamines putrescine, spermidine and spermine. The effects of polyamine deprivation are reversed by N-(2-mercaptoethyl)-1, 3-diaminopropane (WR1065), a simple aminot...

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Bibliographic Details
Main Authors: Mitchell, J L, Rupert, J, Leyser, A, Judd, G G
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219786/
https://ncbi.nlm.nih.gov/pubmed/9761731
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