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Amifostine Metabolite WR-1065 Disrupts Homologous Recombination in Mammalian Cells
Repair of DNA damage through homologous recombination (HR) pathways plays a crucial role in maintaining genome stability. However, overstimulation of HR pathways in response to genotoxic stress may abnormally elevate recombination frequencies, leading to increased mutation rates and delayed genomic...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831807/ https://ncbi.nlm.nih.gov/pubmed/20095849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1982.1 |
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