Amifostine Metabolite WR-1065 Disrupts Homologous Recombination in Mammalian Cells

Repair of DNA damage through homologous recombination (HR) pathways plays a crucial role in maintaining genome stability. However, overstimulation of HR pathways in response to genotoxic stress may abnormally elevate recombination frequencies, leading to increased mutation rates and delayed genomic...

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Detalhes bibliográficos
Main Authors: Dziegielewski, Jaroslaw, Goetz, Wilfried, Murley, Jeffrey S., Grdina, David J., Morgan, William F., Baulch, Janet E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831807/
https://ncbi.nlm.nih.gov/pubmed/20095849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1982.1
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