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Development and Validation of an HPLC Method for Determination of Amifostine and/or Its Metabolite (WR-1065) In Human Plasma Using OPA Derivatization and UV Detection

A rapid, sensitive and reproducible HPLC method was developed and validated for the analysis of amifostine (AMF) and/or its metabolite, WR-1065 in human plasma. The method involves the alkylation of free sulfydryl group with iodoacetic acid followed by derivatization of the drug and its metabolite w...

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Bibliografiske detaljer
Udgivet i:Iran J Pharm Res
Main Authors: Samiei, Nasim, Foroutan, Seyed Mohsen, Shafaati, Alireza, Zarghi, Afshin
Format: Artigo
Sprog:Inglês
Udgivet: Shaheed Beheshti University of Medical Sciences 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673932/
https://ncbi.nlm.nih.gov/pubmed/26664371
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