Sensitive and Rapid HPLC Method for Determination of Memantine in Human Plasma Using OPA Derivatization and Fluorescence Detection: Application to Pharmacokinetic Studies

A rapid, sensitive and reproducible HPLC method was developed and validated for the analysis of memantine in human plasma after derivatization with o-phthaldialdehyde (OPA) and fluorescence detection. Amantadine was used as internal standard. The derivatized memantine and amantadine were eluted in l...

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Bibliografiska uppgifter
Huvudupphovsmän: Zarghi, Afshin, Shafaati, Alireza, Foroutan, Seyed Mohsen, Khoddam, Arash, Madadian, Babak
Materialtyp: Artigo
Språk:Inglês
Publicerad: Österreichische Apotheker-Verlagsgesellschaft 2010
Ämnen:
Original Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007610/
https://ncbi.nlm.nih.gov/pubmed/21179320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3797/scipharm.1008-17
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