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WR‐1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells
The effects of WR‐1065 (2‐((aminopropyl)amino)ethanethiol) on cell cycle progression, topoisomerase (topo) IIα activity, and topo IIα phosphorylation in Chinese hamster ovary (CHO) cells have been investigated. Exposure of CHO cells to 0.4 μm of WR‐1065 for 30 min did not effect cell cycle progressi...
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| Publicado no: | Cell Prolif |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Ltd
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6496680/ https://ncbi.nlm.nih.gov/pubmed/9451419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2184.1997.00092.x |
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