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WR‐1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells

The effects of WR‐1065 (2‐((aminopropyl)amino)ethanethiol) on cell cycle progression, topoisomerase (topo) IIα activity, and topo IIα phosphorylation in Chinese hamster ovary (CHO) cells have been investigated. Exposure of CHO cells to 0.4 μm of WR‐1065 for 30 min did not effect cell cycle progressi...

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Publicat a:Cell Prolif
Autors principals: Murley, J. S., Constantinou, A., Kamath, N. S., Grdina, D. J.
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Ltd 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496680/
https://ncbi.nlm.nih.gov/pubmed/9451419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2184.1997.00092.x
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