Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation

Runx1 is a key hematopoietic transcription factor required for definitive hematopoiesis and is a frequent target of leukemia-related chromosomal translocations. The resulting fusion proteins, while retaining DNA binding activity, display loss of subnuclear targeting and associated transactivation fu...

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Bibliografiska uppgifter
Huvudupphovsmän: Dowdy, Christopher R., Xie, Ronglin, Frederick, Dana, Hussain, Sadiq, Zaidi, Sayyed K., Vradii, Diana, Javed, Amjad, Li, Xiangen, Jones, Stephen N., Lian, Jane B., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830828/
https://ncbi.nlm.nih.gov/pubmed/20035012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp568
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