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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and inhibits osteoblast activity. Here we show that the endogenous Yes-associated protein (YAP), a mediator of Src/Yes signaling, interacts with the native Runx2 protein, an osteoblast-related transcription factor, a...

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Detalhes bibliográficos
Main Authors: Zaidi, Sayyed K, Sullivan, Andrew J, Medina, Ricardo, Ito, Yoshiaki, van Wijnen, Andre J, Stein, Janet L, Lian, Jane B, Stein, Gary S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC380991/
https://ncbi.nlm.nih.gov/pubmed/14765127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600073
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