Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential

The osteogenic Runt-related (Runx2) transcription factor negatively regulates proliferation and ribosomal gene expression in normal diploid osteoblasts, but is up-regulated in metastatic breast and prostate cancer cells. Thus, Runx2 may function as a tumor suppressor or an oncogene depending on the...

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Bibliographic Details
Main Authors: Zaidi, Sayyed K., Pande, Sandhya, Pratap, Jitesh, Gaur, Tripti, Grigoriu, Simina, Ali, Syed A., Stein, Janet L., Lian, Jane B., van Wijnen, Andre J., Stein, Gary S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148388/
https://ncbi.nlm.nih.gov/pubmed/18077419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709650104
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