Učitavanje...
Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential
The osteogenic Runt-related (Runx2) transcription factor negatively regulates proliferation and ribosomal gene expression in normal diploid osteoblasts, but is up-regulated in metastatic breast and prostate cancer cells. Thus, Runx2 may function as a tumor suppressor or an oncogene depending on the...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2148388/ https://ncbi.nlm.nih.gov/pubmed/18077419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709650104 |
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