Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential

The osteogenic Runt-related (Runx2) transcription factor negatively regulates proliferation and ribosomal gene expression in normal diploid osteoblasts, but is up-regulated in metastatic breast and prostate cancer cells. Thus, Runx2 may function as a tumor suppressor or an oncogene depending on the...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zaidi, Sayyed K., Pande, Sandhya, Pratap, Jitesh, Gaur, Tripti, Grigoriu, Simina, Ali, Syed A., Stein, Janet L., Lian, Jane B., van Wijnen, Andre J., Stein, Gary S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148388/
https://ncbi.nlm.nih.gov/pubmed/18077419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709650104
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares