Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

Runx (Cbfa/AML) transcription factors are critical for tissue-specific gene expression. A unique targeting signal in the C terminus directs Runx factors to discrete foci within the nucleus. Using Runx2/CBFA1/AML3 and its essential role in osteogenesis as a model, we investigated the fundamental impo...

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Autors principals: Choi, Je-Yong, Pratap, Jitesh, Javed, Amjad, Zaidi, S. Kaleem, Xing, Lianping, Balint, Eva, Dalamangas, Sara, Boyce, Brendan, van Wijnen, André J., Lian, Jane B., Stein, Janet L., Jones, Stephen N., Stein, Gary S.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC37490/
https://ncbi.nlm.nih.gov/pubmed/11438701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151236498
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