A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation

Definitive hematopoiesis requires the master hematopoietic transcription factor Runx1, which is a frequent target of leukemia-related chromosomal translocations. Several of the translocation-generated fusion proteins retain the DNA binding activity of Runx1, but lose subnuclear targeting and associa...

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Detalhes bibliográficos
Main Authors: Dowdy, Christopher R., Frederick, Dana, Zaidi, Sayyed K., Colby, Jennifer L., Lian, Jane B., van Wijnen, Andre J., Gerstein, Rachel M., Stein, Janet L., Stein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3909992/
https://ncbi.nlm.nih.gov/pubmed/23823022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2013.06.006
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