Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation

Runx1 is a key hematopoietic transcription factor required for definitive hematopoiesis and is a frequent target of leukemia-related chromosomal translocations. The resulting fusion proteins, while retaining DNA binding activity, display loss of subnuclear targeting and associated transactivation fu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dowdy, Christopher R., Xie, Ronglin, Frederick, Dana, Hussain, Sadiq, Zaidi, Sayyed K., Vradii, Diana, Javed, Amjad, Li, Xiangen, Jones, Stephen N., Lian, Jane B., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2010
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830828/
https://ncbi.nlm.nih.gov/pubmed/20035012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp568
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