Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation

Runx1 is a key hematopoietic transcription factor required for definitive hematopoiesis and is a frequent target of leukemia-related chromosomal translocations. The resulting fusion proteins, while retaining DNA binding activity, display loss of subnuclear targeting and associated transactivation fu...

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Main Authors: Dowdy, Christopher R., Xie, Ronglin, Frederick, Dana, Hussain, Sadiq, Zaidi, Sayyed K., Vradii, Diana, Javed, Amjad, Li, Xiangen, Jones, Stephen N., Lian, Jane B., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830828/
https://ncbi.nlm.nih.gov/pubmed/20035012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp568
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