A Runx2 threshold for the cleidocranial dysplasia phenotype

Cleidocranial dysplasia (CCD) in humans is an autosomal-dominant skeletal disease that results from mutations in the bone-specific transcription factor RUNX2 (CBFA1/AML3). However, distinct RUNX2 mutations in CCD do not correlate with the severity of the disease. Here we generated a new mouse model...

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Autori principali: Lou, Yang, Javed, Amjad, Hussain, Sadiq, Colby, Jennifer, Frederick, Dana, Pratap, Jitesh, Xie, Ronglin, Gaur, Tripti, van Wijnen, Andre J., Jones, Stephen N., Stein, Gary S., Lian, Jane B., Stein, Janet L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2009
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638795/
https://ncbi.nlm.nih.gov/pubmed/19028669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn383
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