The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion

The Runx2 (Cbfa1/AML3) transcription factor and matrix metalloproteinase 9 (MMP9) are key regulators of growth plate maturation and bone formation. The genes for both proteins are characteristic markers of breast and prostate cancer cells that metastasize to bone. Here we experimentally addressed th...

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Main Authors: Pratap, Jitesh, Javed, Amjad, Languino, Lucia R., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
主題:
Gene Expression
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265732/
https://ncbi.nlm.nih.gov/pubmed/16166639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8581-8591.2005
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