The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion

The Runx2 (Cbfa1/AML3) transcription factor and matrix metalloproteinase 9 (MMP9) are key regulators of growth plate maturation and bone formation. The genes for both proteins are characteristic markers of breast and prostate cancer cells that metastasize to bone. Here we experimentally addressed th...

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Detalhes bibliográficos
Main Authors: Pratap, Jitesh, Javed, Amjad, Languino, Lucia R., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265732/
https://ncbi.nlm.nih.gov/pubmed/16166639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.19.8581-8591.2005
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