Structural Coupling of Smad and Runx2 for Execution of the BMP2 Osteogenic Signal

Two regulatory pathways, bone morphogenetic protein (BMP)/transforming growth factor-β (TGFβ) and the transcription factor RUNX2, are required for bone formation in vivo. Here we show the interdependent requirement of these pathways to induce an osteogenic program. A panel of Runx2 deletion and poin...

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Autori principali: Javed, Amjad, Bae, Jong-Sup, Afzal, Faiza, Gutierrez, Soraya, Pratap, Jitesh, Zaidi, Sayyed K., Lou, Yang, van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Molecular Basis of Cell and Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2417186/
https://ncbi.nlm.nih.gov/pubmed/18204048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M705578200
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