Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

The severe acute respiratory syndrome coronavirus (SARS-CoV) caused substantial morbidity and mortality in 2002–2003. Deletion of the envelope (E) protein modestly diminished virus growth in tissue culture but abrogated virulence in animals. Here, we show that immunization with rSARS-CoV-ΔE or SARS-...

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Hlavní autoři: Netland, Jason, DeDiego, Marta L., Zhao, Jincun, Fett, Craig, Álvarez, Enrique, Nieto-Torres, José L., Enjuanes, Luis, Perlman, Stanley
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Inc. 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830353/
https://ncbi.nlm.nih.gov/pubmed/20110095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.01.004
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