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Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice

Recombinant severe acute respiratory virus (SARS-CoV) variants lacking the group specific genes 6, 7a, 7b, 8a, 8b and 9b (rSARS-CoV-Δ[6–9b]), the structural gene E (rSARS-CoV-ΔE), and a combination of both sets of genes (rSARS-CoV-Δ[E,6–9b]) have been generated. All these viruses were rescued in mon...

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Detalhes bibliográficos
Main Authors: DeDiego, Marta L., Pewe, Lecia, Alvarez, Enrique, Rejas, Maria Teresa, Perlman, Stanley, Enjuanes, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810402/
https://ncbi.nlm.nih.gov/pubmed/18452964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.03.005
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