Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

The severe acute respiratory syndrome coronavirus (SARS-CoV) caused substantial morbidity and mortality in 2002–2003. Deletion of the envelope (E) protein modestly diminished virus growth in tissue culture but abrogated virulence in animals. Here, we show that immunization with rSARS-CoV-ΔE or SARS-...

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Detalhes bibliográficos
Main Authors: Netland, Jason, DeDiego, Marta L., Zhao, Jincun, Fett, Craig, Álvarez, Enrique, Nieto-Torres, José L., Enjuanes, Luis, Perlman, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830353/
https://ncbi.nlm.nih.gov/pubmed/20110095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.01.004
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