Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

The severe acute respiratory syndrome coronavirus (SARS-CoV) caused substantial morbidity and mortality in 2002–2003. Deletion of the envelope (E) protein modestly diminished virus growth in tissue culture but abrogated virulence in animals. Here, we show that immunization with rSARS-CoV-ΔE or SARS-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Netland, Jason, DeDiego, Marta L., Zhao, Jincun, Fett, Craig, Álvarez, Enrique, Nieto-Torres, José L., Enjuanes, Luis, Perlman, Stanley
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Inc. 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830353/
https://ncbi.nlm.nih.gov/pubmed/20110095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.01.004
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