Severe Acute Respiratory Syndrome Coronaviruses with Mutations in the E Protein Are Attenuated and Promising Vaccine Candidates

Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease with a mortality rate of 10%. A mouse-adapted SARS-CoV (SARS-CoV-MA15) lacking the envelope (E) protein (rSARS-CoV-MA15-ΔE) is attenuated in vivo. To identify E protein regions and host responses that contribute to...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Regla-Nava, Jose A., Nieto-Torres, Jose L., Jimenez-Guardeño, Jose M., Fernandez-Delgado, Raul, Fett, Craig, Castaño-Rodríguez, Carlos, Perlman, Stanley, Enjuanes, Luis, DeDiego, Marta L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403406/
https://ncbi.nlm.nih.gov/pubmed/25609816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03566-14
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