Inhibition of NF-κB-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV lacking the E gene (SARS-CoV-ΔE) is attenuated in several animal model systems. Here, we show that absence of the E protein res...

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Main Authors: DeDiego, Marta L., Nieto-Torres, Jose L., Regla-Nava, Jose A., Jimenez-Guardeño, Jose M., Fernandez-Delgado, Raul, Fett, Craig, Castaño-Rodriguez, Carlos, Perlman, Stanley, Enjuanes, Luis
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911641/
https://ncbi.nlm.nih.gov/pubmed/24198408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02576-13
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