Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

Zoonotic coronaviruses, including the one that caused severe acute respiratory syndrome (SARS), cause significant morbidity and mortality in humans. No specific therapy for any human coronavirus is available, making vaccine development critical for protection against these viruses. We previously sho...

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Detalhes bibliográficos
Main Authors: Fett, Craig, DeDiego, Marta L., Regla-Nava, Jose A., Enjuanes, Luis, Perlman, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676143/
https://ncbi.nlm.nih.gov/pubmed/23576515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00087-13
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