Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

Zoonotic coronaviruses, including the one that caused severe acute respiratory syndrome (SARS), cause significant morbidity and mortality in humans. No specific therapy for any human coronavirus is available, making vaccine development critical for protection against these viruses. We previously sho...

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Détails bibliographiques
Auteurs principaux: Fett, Craig, DeDiego, Marta L., Regla-Nava, Jose A., Enjuanes, Luis, Perlman, Stanley
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2013
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676143/
https://ncbi.nlm.nih.gov/pubmed/23576515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00087-13
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