A Severe Acute Respiratory Syndrome Coronavirus That Lacks the E Gene Is Attenuated In Vitro and In Vivo

A deletion mutant of severe acute respiratory syndrome coronavirus (SARS-CoV) has been engineered by deleting the structural E gene in an infectious cDNA clone that was constructed as a bacterial artificial chromosome (BAC). The recombinant virus lacking the E gene (rSARS-CoV-ΔE) was rescued in Vero...

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Detalhes bibliográficos
Main Authors: DeDiego, Marta L., Álvarez, Enrique, Almazán, Fernando, Rejas, María Teresa, Lamirande, Elaine, Roberts, Anjeanette, Shieh, Wun-Ju, Zaki, Sherif R., Subbarao, Kanta, Enjuanes, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797558/
https://ncbi.nlm.nih.gov/pubmed/17108030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01467-06
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