A Live Attenuated Severe Acute Respiratory Syndrome Coronavirus Is Immunogenic and Efficacious in Golden Syrian Hamsters

The immunogenicity and protective efficacy of a live attenuated vaccine consisting of a recombinant severe acute respiratory syndrome (SARS) coronavirus lacking the E gene (rSARS-CoV-ΔE) were studied using hamsters. Hamsters immunized with rSARS-CoV-ΔE developed high serum-neutralizing antibody tite...

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Detalhes bibliográficos
Main Authors: Lamirande, Elaine W., DeDiego, Marta L., Roberts, Anjeanette, Jackson, Jadon P., Alvarez, Enrique, Sheahan, Tim, Shieh, Wun-Ju, Zaki, Sherif R., Baric, Ralph, Enjuanes, Luis, Subbarao, Kanta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493341/
https://ncbi.nlm.nih.gov/pubmed/18463152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00304-08
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