Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

OBJECTIVE: Mice with complete deletion of insulin receptor substrate 2 (IRS2) develop hyperglycemia, impaired hepatic insulin signaling, and elevated gluconeogenesis, whereas mice deficient for protein tyrosine phosphatase (PTP)1B display an opposing hepatic phenotype characterized by increased sens...

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Détails bibliographiques
Auteurs principaux: González-Rodríguez, Águeda, Gutierrez, Jose A. Mas, Sanz-González, Silvia, Ros, Manuel, Burks, Deborah J., Valverde, Ángela M.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2010
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828646/
https://ncbi.nlm.nih.gov/pubmed/20028942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0796
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