Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

Type 2 diabetes is characterized by abnormalities of insulin action in muscle, adipose tissue, and liver and by altered β-cell function. To analyze the role of the insulin signaling pathway in these processes, we have generated mice with combined heterozygous null mutations in insulin receptor (ir),...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Kido, Yoshiaki, Burks, Deborah J., Withers, Dominic, Bruning, Jens C., Kahn, C. Ronald, White, Morris F., Accili, Domenico
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC377430/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10642598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7917
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