YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase.

Of 34 tyrosine residues in insulin receptor substrate 1 (IRS-1), 14 are adjacent to acidic residues, suggesting that they might be phosphorylation sites. Synthetic peptides corresponding to sequences surrounding these tyrosines were used as substrates of the insulin receptor kinase. Surprisingly six...

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Bibliographische Detailangaben
Hauptverfasser: Shoelson, S E, Chatterjee, S, Chaudhuri, M, White, M F
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC48589/
https://ncbi.nlm.nih.gov/pubmed/1312712
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