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Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility.

Transmembrane (TM) domains of integral membrane proteins are generally thought to be helical. However, a Gly-Pro sequence within the TM domain of the insulin receptor is predicted to act as a helix breaker. CD analyses of model TM peptides in a lipid-like environment show that substitution of Gly an...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Goncalves, E, Yamada, K, Thatte, H S, Backer, J M, Golan, D E, Kahn, C R, Shoelson, S E
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46802/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8390680/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.12.5762
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