Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility.

Transmembrane (TM) domains of integral membrane proteins are generally thought to be helical. However, a Gly-Pro sequence within the TM domain of the insulin receptor is predicted to act as a helix breaker. CD analyses of model TM peptides in a lipid-like environment show that substitution of Gly an...

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Detaylı Bibliyografya
Asıl Yazarlar: Goncalves, E, Yamada, K, Thatte, H S, Backer, J M, Golan, D E, Kahn, C R, Shoelson, S E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1993
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC46802/
https://ncbi.nlm.nih.gov/pubmed/8390680
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