Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling

To investigate the roles of insulin receptor substrate 3 (IRS-3) and IRS-4 in the insulin-like growth factor 1 (IGF-1) signaling cascade, we introduced these proteins into 3T3 embryonic fibroblast cell lines prepared from wild-type (WT) and IRS-1 knockout (KO) mice by using a retroviral system. Foll...

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Autori principali: Tsuruzoe, Kaku, Emkey, Renee, Kriauciunas, Kristina M., Ueki, Kohjiro, Kahn, C. Ronald
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC86565/
https://ncbi.nlm.nih.gov/pubmed/11113178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.26-38.2001
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