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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

Type 2 diabetes is characterized by abnormalities of insulin action in muscle, adipose tissue, and liver and by altered β-cell function. To analyze the role of the insulin signaling pathway in these processes, we have generated mice with combined heterozygous null mutations in insulin receptor (ir),...

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Détails bibliographiques
Auteurs principaux: Kido, Yoshiaki, Burks, Deborah J., Withers, Dominic, Bruning, Jens C., Kahn, C. Ronald, White, Morris F., Accili, Domenico
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC377430/
https://ncbi.nlm.nih.gov/pubmed/10642598
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