Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function

The insulin receptor substrate (IRS) proteins are key mediators of insulin and insulinlike growth factor 1 (IGF-1) signaling. Protein tyrosine phosphatase (PTP)-1B dephosphorylates and inactivates both insulin and IGF-1 receptors. IRS2-deficient mice present altered hepatic insulin signaling and β-c...

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Hlavní autoři: Murillo-Cuesta, Silvia, Camarero, Guadalupe, González-Rodríguez, Águeda, de la Rosa, Lourdes Rodríguez, Burks, Deborah J, Avendaño, Carlos, Valverde, Ángela M, Varela-Nieto, Isabel
Médium: Artigo
Jazyk:Inglês
Vydáno: ScholarOne 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324951/
https://ncbi.nlm.nih.gov/pubmed/22160220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00328
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