Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function

The insulin receptor substrate (IRS) proteins are key mediators of insulin and insulinlike growth factor 1 (IGF-1) signaling. Protein tyrosine phosphatase (PTP)-1B dephosphorylates and inactivates both insulin and IGF-1 receptors. IRS2-deficient mice present altered hepatic insulin signaling and β-c...

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Autori principali: Murillo-Cuesta, Silvia, Camarero, Guadalupe, González-Rodríguez, Águeda, de la Rosa, Lourdes Rodríguez, Burks, Deborah J, Avendaño, Carlos, Valverde, Ángela M, Varela-Nieto, Isabel
Natura: Artigo
Lingua:Inglês
Pubblicazione: ScholarOne 2011
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324951/
https://ncbi.nlm.nih.gov/pubmed/22160220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00328
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