Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

OBJECTIVE: Mice with complete deletion of insulin receptor substrate 2 (IRS2) develop hyperglycemia, impaired hepatic insulin signaling, and elevated gluconeogenesis, whereas mice deficient for protein tyrosine phosphatase (PTP)1B display an opposing hepatic phenotype characterized by increased sens...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: González-Rodríguez, Águeda, Gutierrez, Jose A. Mas, Sanz-González, Silvia, Ros, Manuel, Burks, Deborah J., Valverde, Ángela M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828646/
https://ncbi.nlm.nih.gov/pubmed/20028942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0796
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados